diff --git a/.dockerignore b/.dockerignore
new file mode 100644
index 0000000..dff9e69
--- /dev/null
+++ b/.dockerignore
@@ -0,0 +1,6 @@
+# Build files are ignored to avoid collision and large context
+# in the event someone hasn't run `dub clean` for a while
+*.a
+*.o
+.dub/
+test/*/.dub/
diff --git a/.github/workflows/alpine.yml b/.github/workflows/alpine.yml
new file mode 100644
index 0000000..e0088f9
--- /dev/null
+++ b/.github/workflows/alpine.yml
@@ -0,0 +1,44 @@
+# Build dub on Alpine Linux, testing compatibility with Musl
+name: Alpine
+
+on:
+  pull_request:
+    branches:
+      - master
+      - stable
+  push:
+    branches:
+      - master
+      - stable
+      # Use this branch name in your fork to test changes
+      - github-actions
+
+jobs:
+  main:
+    name: Run
+    strategy:
+      # Default, disable if you want to debug
+      fail-fast: false
+      matrix:
+        include:
+# Disabled as we rely on DIP1000 `foreach (scope)` which GDC < 12 doesn't support
+#          - { dc: gdc, dcpkg: gcc-gdc, dcbin: gdc  }
+          - { dc: ldc, dcpkg: ldc,     dcbin: ldc2 }
+          - { dc: dmd, dcpkg: dmd,     dcbin: dmd  }
+
+    # OS doesn't matter, we just need Docker
+    runs-on: ubuntu-latest
+    steps:
+    # Checkout the repository
+    - name: Checkout
+      uses: actions/checkout@v3
+
+    - name: Build
+      run: |
+        docker build -t alpine-dub-image \
+          --build-arg="DCPKG=${{ matrix.dcpkg}}" \
+          --build-arg="DCBIN=${{ matrix.dcbin}}" \
+          -f docker/Dockerfile.alpine $(pwd)
+
+    - name: Test
+      run: docker run alpine-dub-image
diff --git a/docker/Dockerfile.alpine b/docker/Dockerfile.alpine
new file mode 100644
index 0000000..1ca9941
--- /dev/null
+++ b/docker/Dockerfile.alpine
@@ -0,0 +1,23 @@
+FROM alpine:edge AS Builder
+
+# DCPKG is the name of the package, DCBIN the name of the binary
+# We need this because of the ldc / ldc2 disparity
+ARG DCPKG
+ARG DCBIN
+
+# Build dub (and install tests dependencies in the process)
+WORKDIR /root/build/
+RUN apk add --no-cache bash build-base curl curl-dev dtools dub git grep rsync $DCPKG
+ADD . /root/build/
+RUN dub test --compiler=$DCBIN && dub build --compiler=$DCBIN
+
+# Remove dub to avoid the risk of using the wrong binary
+RUN apk del dub
+
+# Used by the `run-unittest.sh` script
+ENV DUB=/root/build/bin/dub
+ENV DC=$DCBIN
+
+# Finally, just run the test-suite
+WORKDIR /root/build/test/
+ENTRYPOINT [ "/root/build/test/run-unittest.sh" ]