diff --git a/changelog/auto-exclude-main-from-other-configs.dd b/changelog/auto-exclude-main-from-other-configs.dd
new file mode 100644
index 0000000..3398a84
--- /dev/null
+++ b/changelog/auto-exclude-main-from-other-configs.dd
@@ -0,0 +1,12 @@
+Dub will now automatically exclude `mainSourceFile` from other configurations
+
+By default, Dub uses all files it can find under its `sourcePaths`.
+However, a common pattern when dealing with multiple targets is to use
+configurations to represent said targets. In the case those targets are executables,
+users would be forced to add main files from other configurations to the
+`excludedSourceFiles` list, or store the main in a different directory outside of
+the sourcePaths.
+
+To simplify this workflow, Dub will now exclude files listed in mainSourceFile
+for other configuration. In case this is not desirable, the files need to be manually
+added to the `sourceFiles` list.
diff --git a/source/dub/package_.d b/source/dub/package_.d
index c7c7750..98c295b 100644
--- a/source/dub/package_.d
+++ b/source/dub/package_.d
@@ -118,6 +118,7 @@
 
 		checkDubRequirements();
 		fillWithDefaults();
+		mutuallyExcludeMainFiles();
 	}
 
 	/** Searches the given directory for package recipe files.
@@ -740,6 +741,30 @@
 			cnames[c.name] = true;
 		}
 	}
+
+	/// Exclude files listed in mainSourceFile for other configurations unless they are listed in sourceFiles
+	private void mutuallyExcludeMainFiles()
+	{
+		string[] allMainFiles;
+		foreach (ref config; m_info.configurations)
+			if (!config.buildSettings.mainSourceFile.empty())
+				allMainFiles ~= config.buildSettings.mainSourceFile;
+
+		if (allMainFiles.length == 0)
+			return;
+
+		foreach (ref config; m_info.configurations) {
+			import std.algorithm.searching : canFind;
+			auto bs = &config.buildSettings;
+			auto otherMainFiles = allMainFiles.filter!(elem => (elem != bs.mainSourceFile)).array;
+
+			if (bs.sourceFiles.length == 0)
+				bs.excludedSourceFiles[""] ~= otherMainFiles;
+			else
+				foreach (suffix, arr; bs.sourceFiles)
+					bs.excludedSourceFiles[suffix] ~= otherMainFiles.filter!(elem => !canFind(arr, elem)).array;
+		}
+	}
 }
 
 private string determineVersionFromSCM(NativePath path)
diff --git a/test/mutex-main-1/.no_run b/test/mutex-main-1/.no_run
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-1/.no_run
diff --git a/test/mutex-main-1/.no_test b/test/mutex-main-1/.no_test
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-1/.no_test
diff --git a/test/mutex-main-1/dub.json b/test/mutex-main-1/dub.json
new file mode 100644
index 0000000..882df72
--- /dev/null
+++ b/test/mutex-main-1/dub.json
@@ -0,0 +1,24 @@
+{
+	"description": "A minimal D application.",
+	"name": "mutex-main",
+	"targetType": "executable",
+
+	"configurations": [
+		{
+			"name": "app",
+			"targetName": "app",
+			"mainSourceFile": "source/app.d"
+		},
+		{
+			"name": "app2",
+			"targetName": "app2",
+			"mainSourceFile": "source/app2.d"
+		},
+		{
+			"name": "failapp",
+			"targetName": "failapp",
+			"mainSourceFile": "source/app.d",
+			"sourceFiles": ["source/app2.d"]
+		}
+	]
+}
diff --git a/test/mutex-main-1/source/app.d b/test/mutex-main-1/source/app.d
new file mode 100644
index 0000000..0d545d4
--- /dev/null
+++ b/test/mutex-main-1/source/app.d
@@ -0,0 +1,8 @@
+module app;
+
+import std.stdio;
+
+void main()
+{
+	writeln("Edit source/app.d to start your project.");
+}
diff --git a/test/mutex-main-1/source/app2.d b/test/mutex-main-1/source/app2.d
new file mode 100644
index 0000000..3524f0b
--- /dev/null
+++ b/test/mutex-main-1/source/app2.d
@@ -0,0 +1,8 @@
+module app2;
+
+import std.stdio;
+
+void main()
+{
+	writeln("Edit source/app2.d to start your project.");
+}
diff --git a/test/mutex-main-2/.no_run b/test/mutex-main-2/.no_run
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-2/.no_run
diff --git a/test/mutex-main-2/.no_test b/test/mutex-main-2/.no_test
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-2/.no_test
diff --git a/test/mutex-main-2/dub.json b/test/mutex-main-2/dub.json
new file mode 100644
index 0000000..6ca022b
--- /dev/null
+++ b/test/mutex-main-2/dub.json
@@ -0,0 +1,24 @@
+{
+	"description": "A minimal D application.",
+	"name": "mutex-main",
+	"targetType": "executable",
+
+	"configurations": [
+		{
+			"name": "app2",
+			"targetName": "app2",
+			"mainSourceFile": "source/app2.d"
+		},
+		{
+			"name": "app",
+			"targetName": "app",
+			"mainSourceFile": "source/app.d"
+		},
+		{
+			"name": "failapp",
+			"targetName": "failapp",
+			"mainSourceFile": "source/app.d",
+			"sourceFiles": ["source/app2.d"]
+		}
+	]
+}
diff --git a/test/mutex-main-2/source/app.d b/test/mutex-main-2/source/app.d
new file mode 100644
index 0000000..0d545d4
--- /dev/null
+++ b/test/mutex-main-2/source/app.d
@@ -0,0 +1,8 @@
+module app;
+
+import std.stdio;
+
+void main()
+{
+	writeln("Edit source/app.d to start your project.");
+}
diff --git a/test/mutex-main-2/source/app2.d b/test/mutex-main-2/source/app2.d
new file mode 100644
index 0000000..3524f0b
--- /dev/null
+++ b/test/mutex-main-2/source/app2.d
@@ -0,0 +1,8 @@
+module app2;
+
+import std.stdio;
+
+void main()
+{
+	writeln("Edit source/app2.d to start your project.");
+}
diff --git a/test/mutex-main-3/.fail_build b/test/mutex-main-3/.fail_build
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-3/.fail_build
diff --git a/test/mutex-main-3/.no_run b/test/mutex-main-3/.no_run
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-3/.no_run
diff --git a/test/mutex-main-3/.no_test b/test/mutex-main-3/.no_test
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/test/mutex-main-3/.no_test
diff --git a/test/mutex-main-3/dub.json b/test/mutex-main-3/dub.json
new file mode 100644
index 0000000..c5db1fa
--- /dev/null
+++ b/test/mutex-main-3/dub.json
@@ -0,0 +1,24 @@
+{
+	"description": "A minimal D application.",
+	"name": "mutex-main",
+	"targetType": "executable",
+
+	"configurations": [
+		{
+			"name": "failapp",
+			"targetName": "failapp",
+			"mainSourceFile": "source/app.d",
+			"sourceFiles": ["source/app2.d"]
+		},
+		{
+			"name": "app",
+			"targetName": "app",
+			"mainSourceFile": "source/app.d",
+		},
+		{
+			"name": "app2",
+			"targetName": "app2",
+			"mainSourceFile": "source/app2.d"
+		}
+	]
+}
diff --git a/test/mutex-main-3/source/app.d b/test/mutex-main-3/source/app.d
new file mode 100644
index 0000000..0d545d4
--- /dev/null
+++ b/test/mutex-main-3/source/app.d
@@ -0,0 +1,8 @@
+module app;
+
+import std.stdio;
+
+void main()
+{
+	writeln("Edit source/app.d to start your project.");
+}
diff --git a/test/mutex-main-3/source/app2.d b/test/mutex-main-3/source/app2.d
new file mode 100644
index 0000000..3524f0b
--- /dev/null
+++ b/test/mutex-main-3/source/app2.d
@@ -0,0 +1,8 @@
+module app2;
+
+import std.stdio;
+
+void main()
+{
+	writeln("Edit source/app2.d to start your project.");
+}